false 0001819133 0001819133 2021-11-09 2021-11-09





Washington, D.C. 20549









Date of Report (Date of earliest event reported): November 9, 2021




(Exact name of registrant as specified in its charter)




Delaware   001-39485   47-2452488

(State or other jurisdiction

of incorporation)



File Number)


(IRS Employer

Identification No.)

100 Binney St, Suite 700

Cambridge, MA 02142

(Address of principal executive offices, including zip code)

Registrant’s telephone number, including area code: 857-320-4900



Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:


Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)


Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)


Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))


Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:


Title of each class





Name of each exchange

on which registered

Common stock, par value $0.001

per share

  TNGX   The Nasdaq Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.




Item 2.02

Results of Operations and Financial Condition.

On November 9, 2021, Tango Therapeutics, Inc. issued a press release relating to its results of operations and financial condition for the quarter ended September 30, 2021. A copy of the press release is furnished as Exhibit 99.1 to this Form 8-K.

The press release, and the information set forth therein (including Exhibit 99.1), is being furnished pursuant to Item 2.02 of this Current Report on Form 8-K and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that Section. Nor shall such document be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, regardless of any general incorporation language in the filing unless specifically stated so therein.


Item 9.01

Financial Statements and Exhibits.

(d) Exhibits





99.1    Press Release issued by Tango Therapeutics, Inc. on November 9, 2021 relating to its results of operations and financial condition for the quarter ended September 30, 2021.
104    Cover Page Interactive Data File (embedded within the Inline XBRL document).


Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.







Dated: November 9, 2021     By:  

/s/ Douglas Barry

    Name:   Douglas Barry
    Title:   General Counsel

Exhibit 99.1



Tango Therapeutics Reports Third Quarter 2021 Financial Results

and Provides Business Highlights

– Strong cash position of $504 million supports advancing discovery and clinical pipeline into second half of 2024 –

– On track for IND filing in fourth quarter of 2021 for TNG908, an MTA-cooperative PRMT5 inhibitor that is synthetic lethal with MTAP deletion, for multiple cancers

CAMBRIDGE, Mass. – November 9, 2021 – Tango Therapeutics, Inc. (NASDAQ: TNGX), a biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, reported its financial results for the third quarter ended September 30, 2021 and provided business highlights.

“This quarter was highlighted by our transition to a public company. We are pleased to have successfully completed the business combination with BCTG Acquisition Corp. (BCTG), and raised sufficient capital to fund operations into the second half of 2024,” said Barbara Weber, M.D., President and Chief Executive Officer of Tango Therapeutics. “We are focused on progressing our pipeline, and in particular, advancing our lead program, an MTAP-selective PRMT5 inhibitor, TNG908, into the clinic in the first half of 2022. An additional highlight of this quarter, and in of support of our advancing development programs, we are pleased to welcome Dr. Marc Rudoltz as Chief Medical Officer.”

Recent Business Highlights



TNG908, MTA-cooperative PRMT5 inhibitor selective for cancers with MTAP deletion, on track for filing an IND. The Company plans to file an investigational new drug (IND) application in the fourth quarter of 2021 and initiate a Phase 1/2 clinical trial in the first half of 2022. Preclinical efficacy data of TNG908 that showed strong regressions in multiple MTAP deleted solid tumor patient derived xenograft (PDX) models was presented at AACR-NCI-EORTC.



Strengthened the management team with the hires of Dr. Marc Rudoltz as Chief Medical Officer and Doug Barry as General Counsel. In November, the Company announced the senior management appointments of Dr. Rudoltz and Mr. Barry. Dr. Rudoltz brings more than 20 years’ experience leading all phases of clinical drug development to Tango. Mr. Barry has been practicing corporate law for more than 20 years, most recently at Alexion and has extensive experience in public reporting and corporate governance.


Presented preclinical data on lead program and discovery platform at AACR-NCI-EORTC 2021. Last month, the Company presented five abstracts as virtual posters at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. The posters highlight the potential applicability of synthetic lethal drug targeting across a range of cancer types.



Closed business combination with BCTG Acquisition Corp., completing transition to a public company. In August, the Company closed the business combination with BCTG, a special purpose acquisition company (SPAC) sponsored by Boxer Capital, and the private investment in public equity (PIPE) financing, resulting in gross proceeds of $342 million to Tango.

Financial Results

At September 30, 2021, the Company held $503.8 million in cash, cash equivalents and marketable securities, which the company believes to be sufficient to fund operations into the second half of 2024.

Collaboration revenue was $6.8 million for the three months ended September 30, 2021 compared to $(11.3) million for the same period in 2020, which was derived from the Gilead collaboration. The increase was primarily due to the charge against revenue of $11.3 million driven by the amendment to the collaboration agreement with Gilead during the third quarter of 2020. The amendment resulted in a change to the transaction price and a cumulative catch-up adjustment to the revenue previously recognized from the Gilead collaboration.

Research and development expenses were $21.9 million for the three months ended September 30, 2021 compared to $13.0 million for the same period in 2020. The increase was primarily due to expenses relating to our lead product candidate, TNG908, and the advancement of our other drug discovery programs, as well as personnel-related costs, including stock-based compensation, consulting and professional fees.

General and administrative expenses were $4.4 million for the three months ended September 30, 2021, compared to $2.5 million for the same period in 2020. The increase was primarily due to personnel-related costs, including stock-based compensation.

Net loss for the three months ended September 30, 2021, was $19.6 million, or $0.28 per share, compared to a net loss of $26.8 million, or $0.76 per share, in the same period in 2020.

About Tango Therapeutics

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. For more information, please visit www.tangotx.com.

Forward-Looking Statements

Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events, Tango’s future operating performance, goals, expectations, beliefs and development objectives for Tango’s product pipeline. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “goal”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. For example, statements concerning the following include or constitute forward-looking statements: the Company’s strong cash position (of $504 million) will support clinical and discovery pipeline advancement, and operations, into second half of 2024; the Company will make an IND filing in fourth quarter of 2021 (and expects to commence clinical trials in the first half of 2022) for TNG908, an MTA-cooperative PRMT5 inhibitor that is synthetic lethal with MTAP deletion for multiple cancers; the Company will continue to advance its development programs in the future; and the potential applicability of synthetic lethal drug targeting across a range of cancer types, including TNG908. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Tango and its management are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: Tango has a limited operating history and has not generated any revenue to date from drug sales, and may never become profitable; Tango will need to raise capital in the future and if we are unable to raise capital when needed or on attractive terms, we would be forced to delay, scale back or discontinue some of our development programs or future commercialization efforts; Tango may need to spend additional cash resources more quickly than expected to advance our product candidates and conduct clinical trials; we may be unable to advance our preclinical development programs into and through the clinic for safety or efficacy reasons or commercialize our product candidates or we may experience significant delays in doing so as a result of factors beyond Tango’s control; Tango’s approach to the discovery and development of product candidates is novel and unproven, which makes it difficult to predict the time, cost of development, and likelihood of successfully developing any products; Tango may not identify or discover additional product candidates or may expend limited resources to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications that may be more profitable or for which there is a greater likelihood of success; our products candidates may cause adverse or other undesirable side effects that could, among other things, delay or prevent regulatory approval; our dependence on third parties for conducting clinical trials and producing drug product; our ability to obtain and maintain patent and other intellectual property protection for our technology and product candidates or the scope of intellectual property protection obtained is not sufficiently broad;

and delays and other impacts on product development and clinical trials from the COVID-19 pandemic. Additional information concerning risks, uncertainties and assumptions can be found in Tango’s filings with the SEC, including the risk factors referenced in Tango’s Prospectus as filed with the SEC pursuant to Rule 424(b)(3) on October 8, 2021. You should not place undue reliance on forward-looking statements in this presentation, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Tango specifically disclaims any duty to update these forward-looking statements.

Investor Contact:

Sam Martin

Argot Partners


Media Contact:

Joshua R. Mansbach

Argot Partners


Condensed Consolidated Statement of Operations

(In thousands, except share data)



     Three Months Ended
September 30,
    Nine Months Ended
September 30,
     2021     2020     2021     2020  

Total revenue

   $ 6,787     $ (11,261   $ 31,326     $ (1,486













Operating expenses:


Research and development

   $ 21,923     $ 12,977     $ 56,002     $ 34,928  

General and administrative

     4,433       2,518       11,530       6,849  













Total operating expenses

     26,356       15,495       67,532       41,777  













Loss from operations

     (19,569     (26,756     (36,206     (43,263













Other income (expense), net

     41       (46     132       155  













Loss before income taxes

     (19,528     (26,802     (36,074     (43,108

Provision for income taxes

     (62     —         (115     —    













Net loss

   $ (19,590   $ (26,802   $ (36,189   $ (43,108













Net loss per common share – basic and diluted

   $ (0.28   $ (0.76   $ (0.68   $ (1.48

Weighted average number of common shares outstanding
– basic and diluted

     70,160,663       35,069,988       53,397,557       29,176,082  

Condensed Consolidated Balance Sheets

(In thousands)



     September 30,
     December 31,



Current assets:


Cash and cash equivalents

   $ 204,974      $ 28,381  

Marketable securities

     298,831        161,939  

Accounts receivable

     8,000        2,000  

Prepaid expenses and other current assets

     4,534        1,312  







Total current assets

     516,339        193,632  

Property and equipment, net

     4,706        3,823  

Operating lease right-of-use assets

     6,732        7,480  

Restricted cash

     2,279        2,279  

Other assets

     81        38  







Total assets

   $ 530,137      $ 207,252  







Liabilities and Stockholders’ Equity


Current liabilities:


Accounts payable

   $ 3,109      $ 1,841  

Accrued expenses and other current liabilities

     9,978        6,140  

Operating lease liabilities

     1,092        959  

Deferred revenue

     27,807        31,977  







Total current liabilities

     41,986        40,917  

Operating lease liabilities, net of current portion

     6,089        6,925  

Deferred revenue, net of current portion

     116,649        120,805  

Other long-term liabilities

     —          5  







Total liabilities

     164,724        168,652  

Total stockholders’ deficit

     365,413        38,600  







Total liabilities and stockholders’ equity

   $ 530,137      $ 207,252