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100010 - Statement - Condensed Consolidated Balance Sheets
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100020 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
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100030 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) 2
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100040 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)
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100050 - Statement - Condensed Consolidated Statements of Stockholders' Equity
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100060 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)
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995455 - Disclosure - Nature of the Business and Basis of Presentation
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Collaboration Agreements
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995485 - Disclosure - Fair Value Measurements
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995495 - Disclosure - Marketable Securities
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995505 - Disclosure - Supplemental Balance Sheet Information
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995515 - Disclosure - Commitments and Contingencies
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995525 - Disclosure - Redeemable Convertible Preferred Stock
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995535 - Disclosure - Stock-Based Compensation
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995545 - Disclosure - Net Loss Per Share
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995555 - Disclosure - Income Taxes
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995565 - Disclosure - Segment Information
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995575 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995585 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995595 - Disclosure - Fair Value Measurements (Tables)
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995605 - Disclosure - Marketable Securities (Tables)
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995615 - Disclosure - Supplemental Balance Sheet Information (Tables)
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995625 - Disclosure - Stock-Based Compensation (Tables)
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995635 - Disclosure - Net Loss Per Share (Tables)
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995645 - Disclosure - Segment Information (Tables)
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995655 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Details)
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995665 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995675 - Disclosure - Collaboration Agreements - Additional Information (Details)
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995685 - Disclosure - Collaboration Agreements - Additional Information (Details1)
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995695 - Disclosure - Fair Value Measurements - Summary Financial Assets Measured at Fair Value on a Recurring Basis (Details)
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995705 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995725 - Disclosure - Marketable Securities - Summary of Fair Value and Gross Unrealized Losses on Securities (Details)
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995745 - Disclosure - Supplemental Balance Sheet Information - Schedule of Property, Plant and Equipment (Details)
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995755 - Disclosure - Supplemental Balance Sheet Information - Additional Information (Details)
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995765 - Disclosure - Supplemental Balance Sheet Information - Schedule of Accrued Expenses and Other Current Liabilities Current (Details)
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995775 - Disclosure - Supplemental Balance Sheet Information - Schedule of Reconciliation of Cash and Cash Equivalents and Restricted Cash (Details)
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995785 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995795 - Disclosure - Redeemable Convertible Preferred Stock - Additional Information (Details)
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995805 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995815 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details)
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995825 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details)
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995835 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units Activity (Details)
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995845 - Disclosure - Net Loss Per Share - Schedule of Earnings Per Share, Basic and Diluted (Details)
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995855 - Disclosure - Net Loss Per Share - Additional Information (Details)
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995865 - Disclosure - Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details)
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995875 - Disclosure - Income Taxes - Additional Information (Details)
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995885 - Disclosure - Segment Information - Additional Information (Details)
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995895 - Disclosure - Segment Information - Schedule of Segment Expense (Details)
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Statement [Line Items]
Statement [Line Items]
Statement [Line Items]
Plan Name [Domain]
Plan Name [Domain]
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Organization consolidation and presentation Of financial statements.
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Transaction price allocated to performance obligation
Revenue, Remaining Performance Obligation, Amount
Research Extension Fee
Research Extension Fee .
Research extension fee
Fair Value, Recurring and Nonrecurring [Table]
Marketable Security, Unrealized Gain (Loss)
Marketable Securities, Unrealized Gain (Loss), Total
Unrealized loss on marketable securities
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive income (loss):
Number of operating segments
Number of Operating Segments
Weighted Average Exercise Price Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Shares, Outstanding
Balance at the beginning (in Shares)
Balance at the ending (in Shares)
Other, net
Other Noncash Income (Expense)
Other Noncash Income (Expense), Total
Fair Value Hierarchy and NAV [Axis]
Redeemable convertible preferred stock, issued
Temporary Equity, Shares Issued
Redeemable Convertible Preferred Stock Issued
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Segment Reporting, Other Segment Item, Amount
Other segment expenses
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Product and Service [Axis]
Temporary Equity, Par Value
Temporary equity, par value
Finite-Lived Intangible Assets by Major Class [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Sale of Stock [Domain]
Cash and Cash Equivalents [Domain]
Summary of Fair value and Gross Unrealized Losses on Securities
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of shares Cancelled
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Common Stock, Shares, Issued
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
Common Stock Shares
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Stock issued during period shares common stock and pre funded warrants net.
Stock Issued During Period Shares Common Stock And Pre Funded Warrants Net
Issuance of common stock from private placement financing, net (in Shares)
Income Statement [Abstract]
Recently Issued Accounting Pronouncements
Recently Issued Accounting Pronouncements [Policy Text Block]
Disclosure of accounting policy for recently issued accounting pronouncements.
Entity Address, State or Province
Entity Address, State or Province
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under stock plans
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Class of Warrant or Right [Table]
Contract with Customer, Liability, Revenue Recognized
Contract with customer liability, revenue recognized
TNG260 Direct Program Expenses - R&D [Member]
TNG260 direct program expenses - R&D.
TNG260 direct program expenses - R&D [Member]
Securities, Total Fair value
Debt Securities, Available-for-Sale, Unrealized Loss Position
Debt securities considered to be an unrealized loss position
Aggregate Intrinsic Value Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Cover [Abstract]
Net loss per common share - basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Operating expenses:
Operating Expenses [Abstract]
Series B One Preferred Stock [Member]
Series B One Preferred Stock.
Series B-1 Preferred Stock [Member]
Contract with Customer, Liability, Current
Short-term deferred revenue
Deferred revenue
Milestone payments.
Milestone Payments
Milestone payments
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Significant accounting policies.
Investments, Debt and Equity Securities [Abstract]
Commitments And Contingencies Details [Table]
Commitments and Contingencies.
Commitments And Contingencies Details [Table]
Schedule of Cash and Cash Equivalents [Table Text Block]
Schedule of Reconciliation of Cash and Cash Equivalents and Restricted Cash
Share-based Payment Arrangement, Expense
Stock-based compensation expense
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Plan Name [Axis]
Plan Name [Axis]
Segment Reporting [Abstract]
Organization Consolidation And Presentation Of Financial Statements [Table]
Organization consolidation and presentation of financial statements.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of shares, Options outstanding Beginning balance
Number of shares, Options outstanding Ending balance
Current assets:
Assets, Current [Abstract]
Number of shares reserved for issuance
Share based payment arrangement, Shares reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Share-based Payment Arrangement, Disclosure [Abstract]
Share-Based Payment Arrangement, Disclosure [Abstract]
Investment Type [Axis]
Research and development costs
Accrued Research And Development Costs Current
Accrued research and development costs current.
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Facilities and Other Related Expenses - R&D [Member]
Facilities and other related expenses - R&D.
Facilities and other related expenses - R&D [Member]
Weighted Average Grant Date Fair Value Per Share, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Product and Service [Domain]
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive income
Pre-funded warrants.
Pre-funded Warrants [Member]
Pre-funded Warrants [Member]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Contract with Customer, Liability, Noncurrent
Long-term deferred revenue
Deferred revenue, net of current portion
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Fair Value, Recurring [Member]
Fair Value Measurements Recurring [Member]
Schedule of estimated useful lives of the Company's property and equipment.
Schedule Of Estimated Useful Lives Of Property And Equipment [Table Text Block]
Summary of estimated useful lives of property and equipment
Common Stock, Par or Stated Value Per Share
Common Stock, Par or Stated Value Per Share
Stock options to purchase common stock [Member]
Temporary Equity, Carrying Amount, Attributable to Parent
Balance at the beginning
Balance at the ending
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively
Deferred Tax Asset [Domain]
Taxes Payable, Current, Total
Taxes Payable, Current
Income tax payable
Statement of Cash Flows [Abstract]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Restricted Stock [Member]
Restricted Stock Awards [Member]
Unvested restricted common stock [Member]
Equity Components [Axis]
Equity Components [Axis]
Entity Address, Address Line One
Entity Address, Address Line One
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Earnings Per Share, Basic and Diluted
Other Commitments [Axis]
Payroll and employee-related costs
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
Number of Stock Units, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Computer Equipment [Member]
Computer equipment [Member]
Computer Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Accounts payable
Increase (Decrease) in Accounts Payable, Trade
Nonoperating Income (Expense)
Total other income, net
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Number of Stock Units, Unvested and outstanding Ending balance
Number of Stock Units, Unvested and outstanding Beginning balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Amendment Flag
Amendment Flag
Operating lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Schedule Of Accrued Expenses And Other Current Liabilities Current [Table Text Block]
Schedule of accrued expenses and other current liabilities current.
Schedule of Accrued Expenses and Other Current Liabilities Current
Personnel-related expenses - R&D [Member]
Personnel-Related Expenses - R&D [Member]
Personnel-related expenses - R&D.
Net loss
Net loss
Share based payment arrangement,Options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of stock options, (in Shares)
Number of shares Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of shares Options exercisable
Research and Development [Member]
Research and Development Expense [Member]
Equity Component [Domain]
Equity Component [Domain]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
General and administrative
General and Administrative Expense
General and Administrative Expense, Total
Supplemental Balance Sheet Information
Supplemental Balance Sheet Disclosures [Text Block]
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Other income, net
Furniture and Fixtures [Member]
Furniture and fixtures [Member]
Furniture and Fixtures [Member]
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Deferred Revenue, Current, Total
Deferred Revenue, Current
Short-term deferred revenue
Amended Gilead Agreement [Member]
Amended gilead agreement.
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Short-term restricted cash
Restricted Cash, Current
Restricted cash
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock under stock plans, (in shares)
Research Term
Research term.
Research term
Deferred Revenue, Noncurrent, Total
Deferred Revenue, Noncurrent
Long-term deferred revenue
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Weighted Average Exercise Price Cancelled
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Restricted Cash, Noncurrent
Restricted cash, net of current portion
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Class of Stock [Domain]
Class of Stock [Domain]
Class of Stock [Domain]
Collaborative Arrangement Disclosure [Text Block]
Collaboration Agreements
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Common shares outstanding
Finite-Lived Intangible Assets, Major Class Name [Domain]
Revaluation of Right-of-use Asset and Lease Liability Upon Lease Modification
Revaluation of right-of-use asset and lease liability upon lease modification.
Revaluation of right-of-use asset and lease liability upon lease remeasurement
Interest Income (Expense), Net, Total
Interest Income (Expense), Operating
Interest income
Other Commitments [Domain]
2023 Inducement Plan [Member]
Two Thousand Twenty Three Inducement Plan [Member]
Two Thousand Twenty Three Inducement Plan [Member]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Accrued expenses and other liabilities
Increase (Decrease) In Accrued Expenses And Other Liabilities
Increase (decrease) in accrued expenses and other liabilities.
Adjustments to additional paid in capital business combination and pipe financing issuance costs.
Adjustments To Additional Paid In Capital Business Combination And Pipe Financing Issuance Costs
Business combination and PIPE financing, issuance costs
Business combination and PIPE financing, issuance costs
Entity Interactive Data Current
Entity Interactive Data Current
Marketable Securities [Table]
Accounting Standards Update [Domain]
Document Quarterly Report
Document Quarterly Report
Proceeds from issuance of common stock upon exercise of stock options and purchase of shares under employee stock purchase plans.
Proceeds from issuance of common stock upon exercise of stock options and purchase of shares under Employee stock purchase plans
Proceeds from issuance of common stock upon exercise of stock options and purchase of shares under ESPP
Weighted Average Grant Date Fair Value Per Share, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Statistical Measurement [Axis]
Statistical Measurement [Axis]
Total assets
Assets, Fair Value Disclosure
Restricted Cash and Cash Equivalents [Axis]
Fair value assets transfer from Level 1 to Level 2
Fair Value Asset Level1 To Level2 Transfer Amount
Fair value asset level1 to level2 transfer amount.
Summary of Restricted Stock Unit Activity
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Weighted Average Grant Date Fair Value Per Share, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average amortization period
Share-based compensation expense, Period for recognition
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
License Revenue [Member]
License Revenue Member
Statement of Income Location, Balance [Axis]
Total assets
Assets
2021 Plan [Member]
Two thousand and twenty one plan.
Two Thousand And Twenty One Plan [Member]
Number of Stock Units, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Stock Units, Vested
Restricted cash
Restricted Cash and Cash Equivalents, Noncurrent
Restricted Cash and Cash Equivalents, Noncurrent, Total
Entity Address, City or Town
Entity Address, City or Town
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss [Member]
Segments [Axis]
Number of Stock Units, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Depreciation
Depreciation
Depreciation, Total
Depreciation expense
Schedule of Segment Reporting Information, by Segment [Table]
Fair value liabilities transfer from Level 2 to Level 1
Fair Value Liabilities Level2 To Level1 Transfer Amounts
Fair value liabilities level2 to level1 transfer amounts.
Computer Software, Intangible Asset [Member]
Computer Software [Member]
Medivir agreement.
Medivir Agreement [Member]
Medivir Agreement [Member]
Private Placement [Member]
Private Placement [Member]
Share-based Payment Arrangement [Text Block]
Stock-Based Compensation
Construction in Progress [Member]
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Fair Value Disclosures [Abstract]
Stock Issued During Period, Value, New Issues
At-the-market offerings, net of issuance costs
ASU 2023-09 [Member]
Accounting Standards Update 2023-09 [Member]
Current liabilities:
Liabilities, Current [Abstract]
Document Type
Document Type
Accounting Standards Update [Axis]
US Government Agencies Debt Securities [Member]
U.S. Government Agency Bonds [Member]
Title of 12(b) Security
Title of 12(b) Security
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Impairments to marketable securities or reserves for credit losses
Debt and Equity Securities, Gain (Loss), Excluding Other-than-temporary Impairment Loss
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Document Fiscal Period Focus
Research and development
Research and Development Expense
Research and Development Expense, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of shares Granted
Fair value liabilities transfer from Level 1 to Level 2
Fair Value Liabilities Level1 To Level2 Transfer Amounts
Fair value liabilities level1 to level2 transfer amounts.
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Accretion on marketable securities 1.
Accretion On Marketable Securities 1
Accretion on marketable securities
Cash cash equivalents and marketable securities
Cash Cash Equivalents and Marketable Securities
Cash Cash Equivalents and Marketable Securities
Securities Greater than twelve months, Fair value
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price
Financial Instruments [Domain]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Revenue remaining performance obligations expected remaining contractual term
Class of Warrant or Right [Line Items]
Sale of Stock [Axis]
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investments [Domain]
Money Market Funds, at Carrying Value
Cash equivalents, Money market funds
Marketable securities
Marketable Securities, Current
Marketable Securities, Current, Total
Income Taxes
Income Tax Disclosure [Text Block]
Cash paid for leases
Cash Paid For Leases
Cash paid for leases.
Debt Securities, Available-for-Sale [Table]
Gilead Agreement [Member]
Gilead Agreement .
Other current liabilities
Other Accrued Liabilities, Current
Entity Address, Address Line Two
Entity Address, Address Line Two
Liabilities and Equity [Abstract]
Liabilities and Stockholders' Equity
Document Period End Date
Document Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Effective income tax rate
Effective tax rate
Effective Income Tax Rate Reconciliation, Percent
Stockholders' Equity Note [Abstract]
Stockholders' Equity Note [Abstract]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Provision for income taxes
Tax provision or benefit
Provision for income taxes
Trading Symbol
Trading Symbol
Balance at the beginning
Balance at the ending
Equity, Attributable to Parent
Total stockholders' equity
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
US Government Securities, at Carrying Value
Cash equivalents, U.S. Treasury bills
Restricted Stock Units (RSUs) [Member]
RSU [Member]
Sale of Stock, Number of Shares Issued in Transaction
Number of shares sold
Number of units issued in transaction
Deferred revenue
Increase (Decrease) in Deferred Revenue
Redeemable convertible preferred stock shares authorized
Temporary Equity, Shares Authorized
Temporary Equity, Shares Authorized
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Change in accounting principle accounting standards update adopted [true or false]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Unrecognized stock-based compensation expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Unrecognized compensation cost
Schedule of Stock-based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Gross Unrealized Loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Equipment [Member]
Equipment [Member]
Laboratory Equipment [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Marketable Debt Securities [Member]
Marketable Debt Securities .
Marketable Debt Securities [Member]
Stock based compensation expense
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block]
Fair Value Measurements
Operating lease liabilities
Increase (Decrease) In Operating Lease Liabilities
Increase (decrease) in operating lease liabilities.
Security Exchange Name
Security Exchange Name
2021 Employee Stock Purchase Plan [Member]
Two Thousand and Twenty One Employee Stock Purchase Plan [Member]
Two thousand and twenty one employee stock purchase plan.
Commitments and Contingencies.
Commitments And Contingencies Details [Line Items]
Commitments and Contingencies (Details) [Line Items]
TNG348 direct program expenses - R&D [Member]
TNG348 Direct Program Expenses- R&D [Member]
TNG348 direct program expenses- R&D.
Total operating expenses
Operating Expenses
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Axis]
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Maximum [Member]
Liabilities and Equity
Total liabilities and stockholders' equity
Operating lease right-of-use asset
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Supplemental cash flow information:
Supplemental Cash Flow Information [Abstract]
TNG462 Direct Program Expenses - R&D [Member]
TNG462 direct program expenses - R&D.
TNG462 direct program expenses - R&D [Member]
Net loss per common share - diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Leasehold Improvements [Member]
Leasehold improvements [Member]
Leasehold Improvements [Member]
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities
Accrued expenses and other current liabilities.
Total accrued expenses and other current liabilities
Entity Ex Transition Period
Entity Ex Transition Period
Impairments to marketable securities or reserves for credit losses
Other Than Temporary Impairment Loss Debt Securities Reserves Credit losses Available For Sale
Other than temporary impairment loss debt securities reserves credit losses available for sale.
Total liabilities
Liabilities
Fair Value Hierarchy and NAV [Domain]
Total current assets
Assets, Current
Net Cash Provided by (Used in) Investing Activities
Net cash provided by (used in) investing activities
Nonrefundable Upfront Payments Received
Non-refundable upfront payment received
Non-refundable upfront payments received
Stock Issued During Period, Shares, New Issues
At-the-market offerings, net of issuance costs (in shares)
Common stock, shares issued
Entity Filer Category
Entity Filer Category
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Warrants to purchase shares of common stock
Nature of the Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Purchases of marketable securities
Payments to Acquire Marketable Securities
Payments to Acquire Marketable Securities, Total
Nonoperating Income (Expense) [Abstract]
Other income:
Current Fiscal Year End Date
Current Fiscal Year End Date
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Redeemable convertible preferred stock Par or Stated Value Per Share
Temporary Equity, Par or Stated Value Per Share
Temporary Equity, Par or Stated Value Per Share
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Aggregate Intrinsic Value, Options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Marketable securities, Accrued interest
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Total
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Entity Registrant Name
Entity Registrant Name
Securities, Total Unrealized loss
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss, Total
Specified regulatory and sales milestones for genetic context.
Specified Regulatory And Sales Milestones For Genetic Context [Member]
Specified Regulatory And Sales Milestones For Genetic Context [Member]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Net Loss Per Share
Earnings Per Share [Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Investment, Type [Extensible Enumeration]
Weighted-average common stock outstanding - basic
Weighted average number of common shares outstanding - basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Marketable Securities [Abstract]
Common Stock, Shares Authorized
Common Stock, Shares Authorized
Sales and maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from Sale and Maturity of Marketable Securities, Total
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Weighted Average Exercise Price Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Financial Instrument [Axis]
Weighted Average Contractual Term, Options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
General and Administrative [Member]
General and Administrative Expense [Member]
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Accounting Policies [Abstract]
Ownership percentage in common stock
Percentage of Ownership Interest in Equity Investment
Percentage of ownership interest in equity investment.
Schedule of Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Income Tax Disclosure [Abstract]
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Supplemental disclosure of noncash investing and financing activity:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Statement [Table]
Statement [Table]
Property, Plant and Equipment [Table Text Block]
Schedule of Property, Plant and Equipment
Discovery Direct Program Expenses - R&D [Member]
Discovery direct program expenses - R&D.
Discovery direct program expenses - R&D [Member]
Stock issued during period value common stock and pre funded warrants net.
Stock Issued During Period Value Common Stock And Pre Funded Warrants Net
Issuance of common stock from private placement financing, net
Entity File Number
Entity File Number
Segment Information
Segment Reporting Disclosure [Text Block]
Non Rule 10B51 Arr Modified Flag
Non-Rule 10b5-1 Arrangement Modified Flag.
Non-Rule 10b5-1 Arrangement Modified
Net change in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Sesame Agreement
Sesame Agreement [Member]
Sesame Agreement.
Earnings Per Share [Abstract]
TNG456 Direct Program Expenses - R&D [Member]
TNG456 direct program expenses - R&D.
TNG456 direct program expenses - R&D [Member]
Specified regulatory approval and sales milestones.
Specified Regulatory Approval And Sales Milestones [Member]
Specified Regulatory Approval And Sales Milestones [Member]
Statement of Financial Position [Abstract]
Loss from operations
Operating Income (Loss)
Entity Shell Company
Entity Shell Company
Collaboration Agreements [Abstract]
Collaboration Agreements .
Entity Tax Identification Number
Entity Tax Identification Number
Assets
Assets [Abstract]
Security Deposits [Member]
Security deposits.
Entity Current Reporting Status
Entity Current Reporting Status
Weighted Average Contractual Term Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Proceeds From Issuance of Common Stock and Pre-funded Warrants, Net
Proceeds from issuance of common stock and pre-funded warrants, net.
Proceeds from issuance of common stock and pre-funded warrants
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant accounting policies.
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash, cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in accounting principle accounting standards update adoption date
Capital Expenditures Incurred but Not yet Paid
Purchases of property and equipment included in accounts payable and accrued expenses
Stock Options [Member]
Stock Options [Member]
Stock options.
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Research extension fees, variable consideration
Research extension fee variable consideration.
Research Extension Fee Variable Consideration
Other Comprehensive Income (Loss), Tax
Other Comprehensive Income (Loss), Tax, Total
Other comprehensive loss
City Area Code
City Area Code
Total current liabilities
Liabilities, Current
Federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
License fee amount
Sponsored A Licence Program,Fee Amount
Sponsored a license program, fee amount.
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Additional paid-in capital
Additional Paid in Capital
Rule 10B51 Arr Modified Flag
Rule 10b5-1 Arrangement Modified Flag.
Rule 10b5-1 Arrangement Modified
Securities Less than twelve months, Unrealized loss
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss
Two Thousand And Eighteen Gilead Agreement [Member]
Two Thousand And Eighteen Gilead Agreement .
2018 Gilead Agreement [Member]
Computer Software [Member]
Computer Software Member
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Upfront payment.
Upfront Payment
Upfront payment
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Operating lease liabilities
Operating Lease, Liability, Current
Temporary Equity Disclosure [Abstract]
Accumulated Deficit [Member]
Retained Earnings [Member]
Non-refundable upfront payment received
Non Refundable Upfront Payment Received
Non-refundable upfront payment received.
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Property, Plant, and Equipment, Total
Collaboration Revenue [Member]
Collaboration Revenue Member
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Summary of Financial Assets Measured at Fair Value on a Recurring Basis
Document Transition Report
Document Transition Report
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Weighted Average Exercise Price Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Minimum [Member]
Minimum [Member]
Common Stock [Member]
Common Stock [Member]
Restricted Cash
Restricted Cash, Total
Restricted cash
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Weighted Average Grant Date Fair Value Per Share, Unvested and outstanding Ending balance
Weighted Average Grant Date Fair Value Per Share, Unvested and outstanding Beginning balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Other long-term assets
Increase (Decrease) in Other Noncurrent Assets
Noncash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Operating Lease Liabilities from Obtaining Right-of-Use Assets
Operating lease liabilities from obtaining right-of-use assets.
Operating lease liabilities from obtaining right-of-use assets
Fair Value
Debt Securities, Available-for-Sale, Current
Debt Securities, Available-for-sale, Current, Total
Adjustments to reconcile net loss to net cash from operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Statement of Income Location, Balance [Domain]
Other assets
Other Assets, Noncurrent
Other Assets, Noncurrent, Total
Forecasting taxable loss position deferred tax assets member.
Forecasting Taxable Loss Position Deferred Tax Assets [Member]
Segments [Domain]
Specified clinical milestones.
Specified Clinical Milestones [Member]
Specified Clinical Milestones [Member]
Cummulative research extension fee
Cummulative Research Extension Fee
Cummulative research extension fee.
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Milestone payments receivable
Milestone Payments Receivable
Milestone payments receivable.
Securities Less than twelve months, Fair value
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
TNG908 Direct Program Expenses - R&D [Member]
TNG908 direct program expenses - R&D .
TNG908 direct program expenses - R&D [Member]
Redeemable Convertible Preferred Stock
Redeemable Convertible Preferred Stock Disclosure [Text Block]
Redeemable convertible preferred stock disclosure.
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, $0.001 par value; 200,000,000 shares authorized at March 31, 2025 and December 31, 2024, respectively; 108,107,890 and 107,729,343 shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Valuation Allowance by Deferred Tax Asset [Axis]
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Debt Securities, Available-for-sale
Revenue recognized, Cumulative catch-up adjustment
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Modification of Contract
Revenue recognized, cumulative catch-up adjustment
Measurement Frequency [Axis]
Impairments to marketable securities or reserves for credit losses
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Total
Other-than-temporary Impairment Loss, Debt Securities, Available-for-Sale
Commitments and Contingencies
Commitments and contingencies (Note 8)
Securities Greater than twelve months, Unrealized loss
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss
Weighted-average common stock outstanding - diluted
Weighted average number of common shares outstanding - diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Segment Expense
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Number Of Licensed Product
Number Of Licensed Product.
Number of licensed product
Fair value assets transfer from Level 2 to Level 1
Fair Value Asset Level2 To Level1 Transfer Amount
Fair value asset level2 to level1 transfer amount.
Entity Small Business
Entity Small Business
Segment Reporting Information [Line Items]
Total revenue
Revenues
Total collaboration revenue
US Treasury Securities [Member]
U.S. Treasury Bills [Member]
Investments, Fair Value Disclosure
Marketable debt securities
Marketable debt securities
Contractual Obligation
Contractual Obligation, Total
Contractual obligation
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Weighted Average Exercise Price, Options outstanding Ending balance
Weighted Average Exercise Price, Options outstanding Beginning balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Measurement Frequency [Domain]
Share-Based Payment Arrangement, Recognized Amount [Abstract]
Redeemable convertible preferred stock, outstanding
Temporary Equity, Shares Outstanding
Balance at the beginning (in Shares)
Balance at the ending (in Shares)
Redeemable Convertible Preferred Stock Outstanding
TNG961 direct program expenses - R&D [Member]
TNG961 Direct Program Expenses - R&D [Member]
TNG961 Direct Program Expenses - R&D [Member]
Accounts payable
Accounts Payable, Current
Accounts Payable, Current, Total