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<element name="SeriesB1CommonSharesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_SeriesB1CommonSharesMember" substitutionGroup="xbrli:item" />
<element name="ResearchTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_ResearchTerm" substitutionGroup="xbrli:item" />
<element name="NonrefundableUpfrontPaymentsReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_NonrefundableUpfrontPaymentsReceived" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="MilestonePaymentsReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_MilestonePaymentsReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NumberOfLicensedProduct" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_NumberOfLicensedProduct" substitutionGroup="xbrli:item" />
<element name="ResearchExtensionFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_ResearchExtensionFee" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ResearchExtensionFeeVariableConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_ResearchExtensionFeeVariableConsideration" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="SponsoredALicenceProgramfeeAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_SponsoredALicenceProgramfeeAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccountsReceivableCurrentResearchExtensionFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_AccountsReceivableCurrentResearchExtensionFee" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="Contractassetresearchextensionfee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_Contractassetresearchextensionfee" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ReceivableResearchExtensionFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_ReceivableResearchExtensionFee" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="TwoThousandAndEighteenGileadAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_TwoThousandAndEighteenGileadAgreementMember" substitutionGroup="xbrli:item" />
<element name="AmendedGileadAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_AmendedGileadAgreementMember" substitutionGroup="xbrli:item" />
<element name="GileadAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_GileadAgreementMember" substitutionGroup="xbrli:item" />
<element name="GileadAgreementBasedPerformanceMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_GileadAgreementBasedPerformanceMember" substitutionGroup="xbrli:item" />
<element name="GileadLetterAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_GileadLetterAgreementMember" substitutionGroup="xbrli:item" />
<element name="SeriesBOnePreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_SeriesBOnePreferredStockMember" substitutionGroup="xbrli:item" />
<element name="MarketableDebtSecuritiesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_MarketableDebtSecuritiesMember" substitutionGroup="xbrli:item" />
<element name="ComputerSoftwareMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_ComputerSoftwareMember" substitutionGroup="xbrli:item" />
<element name="AccruedResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_AccruedResearchAndDevelopmentCostsCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="HundredBinneyStreetInCambridgeMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_HundredBinneyStreetInCambridgeMember" substitutionGroup="xbrli:item" />
<element name="TheTwoHundredAndOneBrooklineAvenueLeaseMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_TheTwoHundredAndOneBrooklineAvenueLeaseMember" substitutionGroup="xbrli:item" />
<element name="LeaseTerminationAgreementMonthAndYear" type="xbrli:gYearMonthItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_LeaseTerminationAgreementMonthAndYear" substitutionGroup="xbrli:item" />
<element name="UpfrontPaymentsForRentAndTenantImprovements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_UpfrontPaymentsForRentAndTenantImprovements" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AnnualRentPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_AnnualRentPayable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="PercentageOfIncreaseInAnnualRentPayable" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_PercentageOfIncreaseInAnnualRentPayable" substitutionGroup="xbrli:item" />
<element name="MinimumRentPaymentsToBePaidOverOriginalTerm" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_MinimumRentPaymentsToBePaidOverOriginalTerm" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="LetterOfCreditToProvideForAmountThatCollateralizedWithCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_LetterOfCreditToProvideForAmountThatCollateralizedWithCash" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInOperatingLeaseRightOfUseAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_IncreaseDecreaseInOperatingLeaseRightOfUseAsset" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="OtherInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_OtherInformationAbstract" substitutionGroup="xbrli:item" />
<element name="CommitmentsAndContingenciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_CommitmentsAndContingenciesDetailsTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="CommitmentsAndContingenciesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_CommitmentsAndContingenciesDetailsLineItems" substitutionGroup="xbrli:item" />
<element name="MilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_MilestonePayments" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="UpfrontPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_UpfrontPayment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="PaymentsUponTerminationOfAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_PaymentsUponTerminationOfAgreement" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_AgreementAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="AgreementDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_AgreementDomain" substitutionGroup="xbrli:item" />
<element name="HitgenAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_HitgenAgreementMember" substitutionGroup="xbrli:item" />
<element name="MedivirAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_MedivirAgreementMember" substitutionGroup="xbrli:item" />
<element name="SpecifiedRegulatoryApprovalAndSalesMilestonesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_SpecifiedRegulatoryApprovalAndSalesMilestonesMember" substitutionGroup="xbrli:item" />
<element name="SpecifiedClinicalMilestonesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_SpecifiedClinicalMilestonesMember" substitutionGroup="xbrli:item" />
<element name="TemporaryStockIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_TemporaryStockIssuanceCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="RedeemableConvertiblePreferredStockIssuePricePerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_RedeemableConvertiblePreferredStockIssuePricePerShare" substitutionGroup="xbrli:item" />
<element name="TemporaryEquityIssuePricePerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_TemporaryEquityIssuePricePerShare" substitutionGroup="xbrli:item" />
<element name="AggregateTemporaryStockIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_AggregateTemporaryStockIssuanceCosts" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="SeriesBRedeemableConvertiblePreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_SeriesBRedeemableConvertiblePreferredStockMember" substitutionGroup="xbrli:item" />
<element name="FoundersAndAdvisorsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_FoundersAndAdvisorsMember" substitutionGroup="xbrli:item" />
<element name="FounderAndAdvisorsRestrictedStockAwardMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_FounderAndAdvisorsRestrictedStockAwardMember" substitutionGroup="xbrli:item" />
<element name="StockOptionsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_StockOptionsMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndTwentyOnePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_TwoThousandAndTwentyOnePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndTwentyOneEmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_TwoThousandAndTwentyOneEmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item" />
<element name="RestrictedCommonStockAwardMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_RestrictedCommonStockAwardMember" substitutionGroup="xbrli:item" />
<element name="IncomeTaxesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_IncomeTaxesTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="IncomeTaxesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_IncomeTaxesLineItems" substitutionGroup="xbrli:item" />
<element name="OperatingLossCarryForwardWithExpirationOfUsage" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_OperatingLossCarryForwardWithExpirationOfUsage" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="OperatingLossCarryForwardWithExpirationOfUsageIndefinite" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_OperatingLossCarryForwardWithExpirationOfUsageIndefinite" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_OperatingLossCarryforwardsExpirationYear" substitutionGroup="xbrli:item" />
<element name="OperatingLossCarryforwardsExpirationStartingYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_OperatingLossCarryforwardsExpirationStartingYear" substitutionGroup="xbrli:item" />
<element name="TaxCreditCarryforwardExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_TaxCreditCarryforwardExpirationYear" substitutionGroup="xbrli:item" />
<element name="PercentageOfIncreaseInOwnershipPercentageOverAThreeYearPeriod" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_PercentageOfIncreaseInOwnershipPercentageOverAThreeYearPeriod" substitutionGroup="xbrli:item" />
<element name="ResearchAndDevelopmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_ResearchAndDevelopmentMember" substitutionGroup="xbrli:item" />
<element name="ExpirationPeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_ExpirationPeriodAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="ExpirationPeriodDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="tngx_ExpirationPeriodDomain" substitutionGroup="xbrli:item" />
<element name="EffectiveIncomeTaxRateReconciliationTaxCreditsResearchAndDevelopment" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="tngx_EffectiveIncomeTaxRateReconciliationTaxCreditsResearchAndDevelopment" substitutionGroup="xbrli:item" />
<element name="DeferredTaxAssetsOperatingLeaseLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_DeferredTaxAssetsOperatingLeaseLiability" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeferredTaxLiabilitiesDepreciation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="tngx_DeferredTaxLiabilitiesDepreciation" substitutionGroup="xbrli:item" xbrli:balance="credit" />
</schema>
