UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

	SCHEDULE 13G
	Under the Securities Exchange Act of 1934
	(Amendment No.  __)*

	Tango Therapeutics, Inc.
	(Name of Issuer)

	Common Stock
	(Title of Class of Securities)

	87583X109
	(CUSIP Number)

	December 31, 2021
	(Date of Event which Requires Filing of this Statement)

1	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only)   Cormorant Asset Management, LP
2	Check the Appropriate Box if a Member of a Group (See Instructions)
	(a)            [ ]
	(b)            [x]
3	SEC Use Only
4	Citizenship or Place of Organization.   Delaware

Number of Shares Beneficially Owned by Each Reporting Person With	5  Sole Voting Power   0 shares
	6  Shared Voting Power   4,899,184 shares Refer to Item 4 below.
	7  Sole Dispositive Power   0 shares
	8  Shared Dispositive Power   4,899,184 shares Refer to Item 4 below.

9	Aggregate Amount Beneficially Owned by Each Reporting Person   4,899,184 shares Refer to Item 4 below.
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11	Percent of Class Represented by Amount in Row (9)*   5.60% Refer to Item 4 below.
12	Type of Reporting Person (See Instructions)   IA

1	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only)   Bihua Chen
2	Check the Appropriate Box if a Member of a Group (See Instructions)
	(a)            [ ]
	(b)            [x]
3	SEC Use Only
4	Citizenship or Place of Organization.   United States

Number of Shares Beneficially Owned by Each Reporting Person With	5  Sole Voting Power   0 shares
	6  Shared Voting Power   4,899,184 shares Refer to Item 4 below.
	7  Sole Dispositive Power   0 shares
	8  Shared Dispositive Power   4,899,184 shares Refer to Item 4 below.

9	Aggregate Amount Beneficially Owned by Each Reporting Person   4,899,184 shares Refer to Item 4 below.
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11	Percent of Class Represented by Amount in Row (9)*   5.60% Refer to Item 4 below.
12	Type of Reporting Person (See Instructions)   HC

(a)	Name of Issuer
	Tango Therapeutics, Inc.
(b)	Address of Issuer’s Principal Executive Offices
	100 Binney St., Suite 700, Cambridge, MA 02142

(a)	Name of Person Filing
	Cormorant Asset Management, LP Bihua Chen
(b)	Address of Principal Business Office or, if none, Residence
	200 Clarendon Street, 52nd Floor Boston, MA 02116
(c)	Citizenship
	Cormorant Asset Management, LP - Delaware Bihua Chen - United States
(d)	Title of Class of Securities
	Common Stock
(e)	CUSIP Number
	87583X109

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)	[ ]	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
(b)	[ ]	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c)	[ ]	Insurance Company as defined in Section 3(a)(19) of the Act
(d)	[ ]	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e)	[x]	An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
(f)	[ ]	An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
(g)	[x]	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	[ ]	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	[ ]	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	[ ]	A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J);
(k)	[ ]	Group, in accordance with §240.13d-1(b)(1)(ii)(K).

Item 4.

Ownership***

(a)	Amount Beneficially Owned***
	Cormorant Asset Management, LP – 4,899,184 shares Bihua Chen – 4,899,184 shares
(b)	Percent of Class
	Cormorant Asset Management, LP – 5.60% Bihua Chen – 5.60%

(c)	Number of shares as to which such person has:
	(i)	sole power to vote or to direct the vote
		Cormorant Asset Management, LP - 0 shares Bihua Chen - 0 shares
	(ii)	shared power to vote or to direct the vote
		Cormorant Asset Management, LP – 4,899,184 shares Bihua Chen – 4,899,184 shares
	(iii)	sole power to dispose or to direct the disposition of
		Cormorant Asset Management, LP - 0 shares Bihua Chen - 0 shares
	(iv)	shared power to dispose or to direct the disposition of
		Cormorant Asset Management, LP – 4,899,184 shares Bihua Chen – 4,899,184 shares

Item 5.

Ownership of Five Percent or Less of a Class

Item 6.

Ownership of More than Five Percent on Behalf of Another Person

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

Item 8.

Identification and Classification of Members of the Group

Item 9.

Notice of Dissolution of Group

Item 10.

Certification