SECURITIES AND EXCHANGE COMMISSION
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TANGO THERAPEUTICS, INC.
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Your Vote Counts! TANGO THERAPEUTICS, INC. 2022 Annual Meeting Vote by June 7, 2022 11:59 PM ET TANGO THERAPEUTICS, INC. 100 BINNEY ST., SUITE 700 CAMBRIDGE, MA 02142 D84973-P73381 You invested in TANGO THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the shareholder meeting to be held on June 8, 2022. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting them prior to May 25, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to firstname.lastname@example.org. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit www.ProxyVote.com Control # Vote Virtually at the Meeting* June 8, 2022 10:00 AM EDT Smartphone users Point your camera here and vote without entering a control number Virtually at: www.virtualshareholdermeeting.com/TNGX2022 *Please check the meeting materials for any special requirements for meeting attendance. V1.1
Vote at www.ProxyVote.com Board Recommends Voting Items 1. Election of Class I Directors Nominees: For 01) Lesley Ann Calhoun 02) Reid Huber 2. To ratify the selection of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022. For NOTE: The Board of Directors will consider and act upon such other business as may properly come before the meeting or any adjournment thereof. Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. D84974-P73381 THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote on these important matters.