SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response: 0.5

1. Name and Address of Reporting Person* Third Rock Ventures VI, L.P. (Last) (First) (Middle) C/O THIRD ROCK VENTURES, LLC 201 BROOKLINE AVE, SUITE 1401 (Street) BOSTON MA 02215 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 08/11/2023	3. Issuer Name and Ticker or Trading Symbol Tango Therapeutics, Inc. [ TNGX ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	194,174(1)	D(2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* Third Rock Ventures VI, L.P. (Last) (First) (Middle) C/O THIRD ROCK VENTURES, LLC 201 BROOKLINE AVE, SUITE 1401 (Street) BOSTON MA 02215 (City) (State) (Zip)

1. Name and Address of Reporting Person* Third Rock Ventures GP VI, L.P. (Last) (First) (Middle) C/O THIRD ROCK VENTURES, LLC 201 BROOKLINE AVE, SUITE 1401 (Street) BOSTON MA 02215 (City) (State) (Zip)

1. Name and Address of Reporting Person* TRV GP VI, LLC (Last) (First) (Middle) C/O THIRD ROCK VENTURES, LLC 201 BROOKLINE AVE, SUITE 1401 (Street) BOSTON MA 02215 (City) (State) (Zip)

Explanation of Responses:

1. The shares of common stock were acquired by the Reporting Person pursuant to a securities purchase agreement in a private placement offering of shares of the Issuer's common stock, which offering closed on August 11, 2023.

2. These shares are directly held by Third Rock Ventures VI, L.P. ("TRV VI"). The general partner of TRV VI is Third Rock Ventures GP VI, L.P. ("TRV GP VI"). The general partner of TRV GP VI is TRV GP VI, LLC ("TRV GP VI LLC"). Each of TRV GP VI and TRV GP VI LLC disclaims beneficial ownership of the shares except to the extent of its pecuniary interest therein, if any, and this report shall not be deemed an admission that it is the beneficial owner of such shares.

Remarks:

Reid Huber, a partner at Third Rock Ventures, LLC, has been deputized to represent the Reporting Persons (and other funds affiliated with Third Rock Ventures, LLC that hold shares of the Issuer's stock) on the board of directors of the Issuer. By virtue of Mr. Huber's representation, for purposes of Section 16 of the Securities Exchange Act of 1934, each of the Reporting Person may be deemed directors by deputization of the Issuer.

	/s/ Kevin Gillis, Chief Operating Officer of TRV GP VI, LLC, general partner of Third Rock Ventures GP VI, L.P., general partner of Third Rock Ventures VI, L.P.	08/22/2023
	/s/ Kevin Gillis, Chief Operating Officer of TRV GP VI, LLC, general partner of Third Rock Ventures GP VI, L.P.	08/22/2023
	/s/ Kevin Gillis, Chief Operating Officer of TRV GP VI, LLC	08/22/2023
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.